Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release.

@article{Chimalakonda2015DevelopmentAV,
  title={Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release.},
  author={Krishna C Chimalakonda and Eric S Pang and J L Weaver and Kristina E Howard and Vikram Patel and Michael T. Boyne},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2015},
  volume={102},
  pages={494-9}
}
Histamine is an important biogenic amine involved in regulating numerous physiological and pathophysiological processes in humans and animals. To date, there have been very few studies focused on developing and validating sensitive liquid-chromatography-tandem mass spectrometric (LC-MS/MS) assays capable of quantitative trace level histamine analysis in… CONTINUE READING