Development and validation of a new monoclonal antibody to mammalian aromatase.

  title={Development and validation of a new monoclonal antibody to mammalian aromatase.},
  author={Katie J Turner and Sheila Macpherson and Michael R Millar and Alan McNeilly and Karin Williams and Mark Cranfield and Nigel Patrick Groome and Richard M. Sharpe and Hamish M. Fraser and Philippa T. K. Saunders},
  journal={The Journal of endocrinology},
  volume={172 1},
The biosynthesis of oestrogens from androgens is catalysed by the aromatase complex, an essential component of which is the aromatase cytochrome P450 (P450 arom) protein. Expression of a functional P450 arom is essential for normal fertility in males and females and the sequence of the protein is highly conserved. We have raised a new monoclonal antibody against a conserved peptide and validated it on fixed tissue sections of the rat, common marmoset (Callthrix jacchus) and human. The… CONTINUE READING


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