Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.

@article{Herbrink2018DevelopmentAV,
  title={Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.},
  author={M Herbrink and Nico de Vries and Hilde Rosing and Alwin D. R. Huitema and Bastiaan Nuijen and Jan H. M. Schellens and Jos H. Beijnen},
  journal={Biomedical chromatography : BMC},
  year={2018},
  volume={32 4}
}
To support therapeutic drug monitoring of patients with cancer, a fast and accurate method for simultaneous quantification of the registered anticancer drugs afatinib, axitinib, ceritinib, crizotinib, dabrafenib, enzalutamide, regorafenib and trametinib in human plasma using liquid chromatography tandem mass spectrometry was developed and validated. Human… CONTINUE READING