Development and validation of a high-sensitivity assay for an antipsychotic agent, CP-88,059, with solid-phase extraction and narrow-bore high-performance liquid chromatography.

@article{Janiszewski1995DevelopmentAV,
  title={Development and validation of a high-sensitivity assay for an antipsychotic agent, CP-88,059, with solid-phase extraction and narrow-bore high-performance liquid chromatography.},
  author={John S. Janiszewski and Hassan G. Fouda and Roderic O. Cole},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1995},
  volume={668 1},
  pages={133-9}
}
An analytical method has been developed and validated for the quantitation of CP-88,059 in human serum. The compound and internal standard were extracted from serum by solid-phase extraction with a weak cation-exchange phase. The analytes were resolved from endogenous interferences using narrow-bore (2.1 mm I.D.) C18 reversed-phase HPLC. Column effluent was… CONTINUE READING