Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats.

@article{Lu2015DevelopmentAV,
  title={Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats.},
  author={Y. Lu and X. Wang and Xiaochun Wang and Jun-Yi Liu and P. Li and H. Ren and Y. Lou and Chuang Lu and Guoliang Zhang},
  journal={Biomedical chromatography : BMC},
  year={2015},
  volume={29 10},
  pages={
          1548-52
        }
}
A sensitive and selective high-performance liquid chromatographic (HPLC) method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor in rat plasma, was developed and validated. Chromatographic separation of W-1 and megestrol acetate (internal standard) was achieved on a reversed-phase C18 column at 25°C. The mobile phase was consisted of acetonitrile-water (60:40, v/v) and pumped at a flow rate of 1.0 mL/min. The ultraviolet… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Validated RP-HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats.
  • 14
Rapid and sensitive LC-MS/MS method for determination of megestrol acetate in human plasma: application to a human pharmacokinetic study.
  • 7
Simple and rapid determination of nevirapine in human serum by reversed-phase high-performance liquid chromatography.
  • 37
Pharmacokinetics of dronedarone in rat using a newly developed high-performance liquid chromatographic assay method.
  • 5
A validated new method for nevirapine quantitation in human plasma via high-performance liquid chromatography.
  • 23
Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.
  • N. Rezk, R. Tidwell, A. Kashuba
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2002
  • 38
Simultaneous determination of three glucuronide conjugates of scutellarein in rat plasma by LC-MS/MS for pharmacokinetic study of breviscapine.
  • 14
Quality by design (QbD) based development and validation of an HPLC method for amiodarone hydrochloride and its impurities in the drug substance.
  • 21
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