Development and validation of a fast RP-HPLC method for the determination of clobetasol propionate in topical nanocapsule suspensions.

@article{Fontana2010DevelopmentAV,
  title={Development and validation of a fast RP-HPLC method for the determination of clobetasol propionate in topical nanocapsule suspensions.},
  author={M{\'a}rcia Camponogara Fontana and M O Bastos and Ruy Carlos Ruver Beck},
  journal={Journal of chromatographic science},
  year={2010},
  volume={48 8},
  pages={637-40}
}
A simple and rapid high-performance liquid chromatographic method is validated for the determination of clobetasol propionate in topical nanocapsule suspensions. The method is carried out on an RP-18 column with a mobile phase composed of methanol-water (80:20 v/v) and UV detection at 241 nm. The method validation yields good results with respect to linearity, specificity, precision, accuracy, and robustness. The calibration curve in the range of 5.0-40.0 microg/mL shows a correlation… CONTINUE READING

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