Development and validation of a chiral liquid chromatographic method for determination of S-isomer in cinacalcet API

A reversed phase enantioselective high performance liquid chromatographic method was developed and validated for determination ofS-enantiomer in Cinacalcet drug substance. The enantiomers of Cinacalcet were resolved on a Chiralcel-OJH (250mmx4.6mm, 5microns) column using a mobile phase system containing n-Hexane, ethanol and n-butyl amine (90:10:1). The… CONTINUE READING