Development and validation of a stability-indicating RP-HPLC method to separate low levels of dexamethasone and other related compounds from betamethasone.

@article{Xiong2009DevelopmentAV,
  title={Development and validation of a stability-indicating RP-HPLC method to separate low levels of dexamethasone and other related compounds from betamethasone.},
  author={Yuan Xiong and Kang Ping Xiao and Abu M Rustum},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2009},
  volume={49 3},
  pages={646-54}
}
Betamethasone (BM) is an active pharmaceutical ingredient (API) or an intermediate which is used to manufacture various finished pharmaceutical products. Betamethasone is also used as a starting material to manufacture other APIs that are related to this steroid family. It is quite a challenging task to separate dexamethasone (DM) peak (the alpha epimer) and other structurally related compounds from BM. A stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC… CONTINUE READING

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