Development and validation of a HPLC-MS-MS method for quantification of metronidazole in human plasma.

@article{Silva2009DevelopmentAV,
  title={Development and validation of a HPLC-MS-MS method for quantification of metronidazole in human plasma.},
  author={Marina de Freitas Silva and Simone Schramm and Eunice Kazue Kano and Eunice Emiko Mori Koono and Valentina Della Porta and Cristina Helena R Serra},
  journal={Journal of chromatographic science},
  year={2009},
  volume={47 9},
  pages={
          781-4
        }
}
The objective of this study was to describe an analytical validation of a simple, rapid, sensitive, and selective liquid chromatography (LC)-tandem mass spectrometry (MS-MS) method for quantification of metronidazole in human plasma samples from bioavailability studies. The plasma samples were pre-treated by liquid-liquid extraction (LLE) with ethyl acetate. Metronidazole and the internal standard (IS) zidovudine were analyzed by combined reversed-phase LC-MS-MS with positive ion electrospray… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 15 REFERENCES

Simultaneous determination of metronidazole and spiramycin I in human plasma , saliva and gingival crevicular fulid by LC – MS / MS

  • A. Salvador Sagan, D. Dubreuil, P. P. Poulet, D. Duffaut, I. Brumpt
  • J . Pharm . Biomed . Anal .
  • 2005

Determination of therapeutic levels of metronidazole in plasma by gas - liquid Chromatography

  • I. J. McGilveray, J. K. Cooper
  • J . Chromatogr .
  • 2001

Validation of a method for detection and confirmation of nitroimidazoles and the corresponding hydroxyl metabolites in pig plasma by high performace liquid - chromatography – tandem mass spectrometry

  • V. Derop Fraselle, J-M. Degroodt, J. V. Loco
  • Anal . Chim . Acta .
  • 2000

Similar Papers

Loading similar papers…