Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood.

@article{Nikolaou2015DevelopmentAV,
  title={Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood.},
  author={Panagiota D Nikolaou and Ioannis I Papoutsis and Artemisia Dona and Chara A Spiliopoulou and Sotiris A Athanaselis},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2015},
  volume={102},
  pages={
          25-32
        }
}
A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extraction (SPE) procedure using HF Bond Elut C18 columns followed by derivatization using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MTBSTFA) with 1% tert-butyldimethylsilyl chloride (TBDMSCl) was used. In this assay, levetiracetam-d6 was used as internal standard. Limits of detection and… CONTINUE READING

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