Development and validation of RP-HPLC method to determine letrozole in different pharmaceutical formulations and its application to studies of drug release from nanoparticles.

@article{Mondal2009DevelopmentAV,
  title={Development and validation of RP-HPLC method to determine letrozole in different pharmaceutical formulations and its application to studies of drug release from nanoparticles.},
  author={Nita Mondal and Tapan Kumar Pal and Saroj Kumar Ghosal},
  journal={Acta poloniae pharmaceutica},
  year={2009},
  volume={66 1},
  pages={
          11-7
        }
}
This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RP-HPLC) method for estimation of letrozole, a new aromatase inhibitor, in raw material, pharmaceutical formulations like tablets and nanoparticles and in release medium. The chromatographic system consisted of a FinePak C, column, an isocratic mobile phase composed of deionized water, acetonitrile and methanol (50:30:20 v/v/v) and UV detection at 240 nm. Letrozole was eluted… CONTINUE READING

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