Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel.

@article{Choudhury2014DevelopmentAV,
  title={Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel.},
  author={Hira Choudhury and Bapi Gorain and Sanmoy Karmakar and Tapan Kumar Pal},
  journal={Journal of chromatographic science},
  year={2014},
  volume={52 1},
  pages={68-74}
}
A simple, reproducible, feasible and innovative reversed-phase high-performance liquid chromatographic method was developed and validated for the quantitative determination of paclitaxel dissolved in various oils. The method was validated after extraction of the analyte from capryol 90, triacetin and olive oil. The method was conducted on a Hypersil BDS C18 column, 250 × 4.6 mm, 5 µm particle size, with a mobile phase composed of acetonitrile: 10 mM KH2PO4 buffer (pH 3.5) (55:45, v/v) and… CONTINUE READING

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