Development and validation of LC-MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma.

Abstract

Dabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration to dabigatran (DAB)-a directly acting oral anticoagulant. In this study, an LC-MSMS assay was developed and validated for the determination of DABE, free DAB and its equipotent O-glucuronide conjugates in plasma. Owing to the susceptibility of DABE and… (More)
DOI: 10.1016/j.jchromb.2015.02.042

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Cite this paper

@article{Nouman2015DevelopmentAV, title={Development and validation of LC-MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma.}, author={Eman G Nouman and Medhat A Al-Ghobashy and Hayam M. Lotfy}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2015}, volume={989}, pages={37-45} }