Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation.

Abstract

A novel simple isocratic HPLC method with UV detection for the determination of three compounds in spray solution (active component clotrimazole and two degradation products imidazole and (2-chlorophenyl)diphenylmethanol) using ibuprofen as an internal standard was developed and validated. The complications with different acido-basic properties of the… (More)
DOI: 10.1016/j.talanta.2007.04.023

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@article{Hjkov2007DevelopmentAV, title={Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation.}, author={Renata H{\'a}jkov{\'a} and Hana Sklen{\'a}řov{\'a} and Ludmila Matysova and Petra {\vS}vecov{\'a} and Petr Solich}, journal={Talanta}, year={2007}, volume={73 3}, pages={483-9} }