Development and tolerance of natural killer cells.

  title={Development and tolerance of natural killer cells.},
  author={David H Raulet},
  journal={Current opinion in immunology},
  volume={11 2},
A natural killer (NK)/T-cell-restricted progenitor cell in the fetal blood, with a phenotype of NK1.1(+) CD117 (c-kit)+, can give rise to NK cells. IL-15 is probably required for NK cell differentiation and, in addition, stimulates expression of at least one of the MHC-specific inhibitory receptor families expressed by NK cells. Evidence supports the role of multiple mechanisms in rendering NK cells self tolerant - including selection for expression of self-specific inhibitory receptors, anergy… CONTINUE READING