Development and statistical validation of a guinea pig model for vaccine potency testing against Infectious Bovine Rhinothracheitis (IBR) virus.

@article{Parreo2010DevelopmentAS,
  title={Development and statistical validation of a guinea pig model for vaccine potency testing against Infectious Bovine Rhinothracheitis (IBR) virus.},
  author={Viviana Gladys Parre{\~n}o and Mar{\'i}a Virginia L{\'o}pez and Daniela Huaman Rodriguez and Mar{\'i}a Marta Vena and Mercedes Izuel and Jorge L. Filippi and A. Garrido Romera and Claudia Faverin and Rodolfo Bellinzoni and Fernando P{\'e}rez Fern{\'a}ndez and Laura Marangunich},
  journal={Vaccine},
  year={2010},
  volume={28 13},
  pages={
          2539-49
        }
}
Infectious Bovine Rhinothracheitis (IBR) caused by bovine herpesvirus 1 (BoHV-1) infection is distributed worldwide. BoHV-1 either alone or in association with other respiratory cattle pathogens causes significant economic losses to the livestock industry. The aim of this work was to validate a guinea pig model as an alternative method to the current BoHV-1 vaccine potency testing in calves. Guinea pigs were immunized with two doses of vaccine, 21 days apart and sampled at 30 days post… CONTINUE READING
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