Development and reorganization of corticospinal projections in EphA4 deficient mice.

  title={Development and reorganization of corticospinal projections in EphA4 deficient mice.},
  author={Jason R. Coonan and Ursula Greferath and Jonathan Messenger and Lynne Hartley and Mark Murphy and Andrew W. Boyd and Mirella Dottori and Mary Pauline Galea and Perry F. Bartlett},
  journal={The Journal of comparative neurology},
  volume={436 2},
The Eph family of receptor tyrosine kinases and their ligands, the ephrins, are important regulators of axon guidance and cell migration in the developing nervous system. Inactivation of the EphA4 gene results in axon guidance defects of the corticospinal tract, a major descending motor pathway that originates in the cortex and terminates at all levels of the spinal cord. In this investigation, we report that although the initial development of the corticospinal projection is normal through the… CONTINUE READING
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