Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.

@article{Vyhlidal2004DevelopmentAR,
  title={Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.},
  author={Carrie A. Vyhlidal and Peter K. Rogan and J. Steven Leeder},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 45},
  pages={46779-86}
}
The pregnane X receptor (PXR) acts as a receptor to induce gene expression in response to structurally diverse xenobiotics through binding as a heterodimer with the 9-cis retinoic acid receptor (RXR) to enhancers in target gene promoters. We identified and estimated the affinities of novel PXR/RXR binding sites in regulated genes and additional genomic targets of PXR with an information theory-based model of the PXR/RXR binding site. Our initial PXR/RXR model, the result of the alignment of 15… CONTINUE READING
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