Development and progression of renal disease in Pima Indians with non-insulin-dependent diabetes mellitus. Diabetic Renal Disease Study Group.

@article{Nelson1996DevelopmentAP,
  title={Development and progression of renal disease in Pima Indians with non-insulin-dependent diabetes mellitus. Diabetic Renal Disease Study Group.},
  author={Robert G Nelson and Peter H. Bennett and Gerald J. Beck and M Z Tan and William C. Knowler and William E. Mitch and Gladys H Hirschman and Bryan D. Myers},
  journal={The New England journal of medicine},
  year={1996},
  volume={335 22},
  pages={1636-42}
}
BACKGROUND Non-insulin-dependent diabetes mellitus (NIDDM) is a major cause of end-stage renal disease. However, the course and determinants of renal failure in this type of diabetes have not been clearly defined. METHODS We studied glomerular function at intervals of 6 to 12 months for 4 years in 194 Pima Indians selected to represent different stages in the development and progression of diabetic renal disease. Initially, 31 subjects had normal glucose tolerance, 29 had impaired glucose… CONTINUE READING

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