Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents.

@article{Lien2011DevelopmentAP,
  title={Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents.},
  author={Cynthia A. Lien},
  journal={British journal of anaesthesia},
  year={2011},
  volume={107 Suppl 1},
  pages={i60-71}
}
Developing a non-depolarizing neuromuscular blocking agent that, like succinylcholine, has a rapid onset and a short duration of effect remains a goal of ongoing research. While rocuronium fills a portion of this need, the large doses required for rapid intubation render it a much longer-acting neuromuscular blocking agent. Postoperative residual neuromuscular block (NMB) is an increasingly recognized complication of non-depolarizing neuromuscular blocking agents. This occurs because of dosing… CONTINUE READING