Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients.

@article{Reinhardt2007DevelopmentAP,
  title={Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients.},
  author={Anita K Reinhardt and Thilo K{\"o}hler and Paul Wood and Peter Rohner and J H Dumas and Bara Ricou and Christian van Delden},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 4},
  pages={1341-50}
}
Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of the selective pressure. We investigated the rapidity of selection, as well as the persistence, of antimicrobial resistance and determined the underlying mechanisms… CONTINUE READING