Development and optimization of novel controlled-release pioglitazone provesicular powders using 32 factorial design

@article{Shukr2014DevelopmentAO,
  title={Development and optimization of novel controlled-release pioglitazone provesicular powders using 32 factorial design},
  author={Marwa Hassan Shukr and Nadia Abdalla Eltablawy},
  journal={Drug Delivery and Translational Research},
  year={2014},
  volume={5},
  pages={51-62}
}
This work aimed at studying a novel controlled drug delivery proniosomal formulation of pioglitazone for treatment of diabetes type-2. The effects of independent variables like type of surfactant and ratio of surfactants/cholesterol were studied using 32 factorial design. The provesicular powders were characterized regarding their encapsulation efficiency, vesicle size, morphology, and in vitro drug release. The revealed optimal provesicular powder was exposed to stability testing and in vivo… CONTINUE READING
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