Development and neurophysiology of mentalizing.

@article{Frith2003DevelopmentAN,
  title={Development and neurophysiology of mentalizing.},
  author={Uta Frith and Chris D. Frith},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2003},
  volume={358 1431},
  pages={
          459-73
        }
}
  • U. Frith, C. Frith
  • Published 29 March 2003
  • Psychology, Biology
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
The mentalizing (theory of mind) system of the brain is probably in operation from ca. 18 months of age, allowing implicit attribution of intentions and other mental states. Between the ages of 4 and 6 years explicit mentalizing becomes possible, and from this age children are able to explain the misleading reasons that have given rise to a false belief. Neuroimaging studies of mentalizing have so far only been carried out in adults. They reveal a system with three components consistently… 
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References

SHOWING 1-10 OF 210 REFERENCES
Interacting minds--a biological basis.
TLDR
Observations suggest that the ability to mentalize has evolved from a system for representing actions, and medial prefrontal regions are concerned with explicit representation of states of the self.
Modeling other minds
TLDR
Nine normal volunteers performed a ‘theory of mind’ task while their regional brain blood flow pattern was recorded using the PET [15O]H2O technique, suggesting that when inferential reasoning depends on constructing a mental model about the beliefs and intentions of others, the participation of the prefrontal cortex is required.
Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension
A PET Investigation of the Attribution of Intentions with a Nonverbal Task
TLDR
The data suggest that attribution of intentions to others is associated with a complex cerebral activity involving the right medial prefrontal cortex when a nonverbal task is used.
"Theory of mind" impairments and their relationship to executive functioning following frontal lobe excisions.
TLDR
The theory of mind was investigated in patients with unilateral frontal lobe lesions and the ability to infer first- and second-order beliefs was tested by requiring subjects to listen to stories in which a protagonist acted upon a false belief.
Cognitive and emotional influences in anterior cingulate cortex
Movement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional Movement Patterns
TLDR
A functional neuroimaging study with positron emission tomography in which six healthy adult volunteers were scanned while watching silent computer-presented animations showed increased activation in association with mental state attribution in four main regions: medial prefrontal cortex, temporoparietal junction, basal temporal regions, and extrastriate cortex.
Mind Reading: Neural Mechanisms of Theory of Mind and Self-Perspective
TLDR
Divergent neural activations in response to TOM and SELF suggest that these important differential mental capacities of human self-consciousness are implemented at least in part in distinct brain regions.
Dissociative methods in the study of frontal lobe function
TLDR
Results suggest that well-defined regions of frontal cortex - middorsolateral, midventrolateral, and dorsal anterior cingulate - have somewhat dynamic functions, adapting themselves to solution of a broad range of cognitive problems.
Pretending and believing: issues in the theory of ToMM
...
...