Development and large scale benchmark testing of the PROSPECTOR_3 threading algorithm.

@article{Skolnick2004DevelopmentAL,
  title={Development and large scale benchmark testing of the PROSPECTOR_3 threading algorithm.},
  author={Jeffrey Skolnick and Daisuke Kihara and Yang Zhang},
  journal={Proteins},
  year={2004},
  volume={56 3},
  pages={502-18}
}
This article describes the PROSPECTOR_3 threading algorithm, which combines various scoring functions designed to match structurally related target/template pairs. Each variant described was found to have a Z-score above which most identified templates have good structural (threading) alignments, Z(struct) (Z(good)). 'Easy' targets with accurate threading alignments are identified as single templates with Z > Z(good) or two templates, each with Z > Z(struct), having a good consensus structure… CONTINUE READING

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