Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system.

@article{Machado2016DevelopmentAI,
  title={Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system.},
  author={Alexandra Moniz Freire Machado and Cassilda Cunha-Reis and Francisca Pereira de Ara{\'u}jo and Rute Nunes and V{\'i}tor Seabra and Domingos Ferreira and Jos{\'e} das Neves and Bruno Sarmento},
  journal={Acta biomaterialia},
  year={2016},
  volume={44},
  pages={
          332-40
        }
}
UNLABELLED Topical pre-exposure prophylaxis (PrEP) with antiretroviral drugs holds promise in preventing vaginal transmission of HIV. However, significant biomedical and social issues found in multiple past clinical trials still need to be addressed in order to optimize protection and users' adherence. One approach may be the development of improved microbicide products. A novel delivery platform comprising drug-loaded nanoparticles (NPs) incorporated into a thin polymeric film base (NPs-in… CONTINUE READING
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Citations

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SHOWING 1-7 OF 7 CITATIONS

Nanoparticle Encapsulation for Antiretroviral Pre-Exposure Prophylaxis

  • Journal of nanotechnology and materials science
  • 2017
VIEW 11 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

José das Neves, Francisca Araújo, +3 authors Bruno Sarmento
  • Pharmaceutical Research
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

In vitro and in vivo: the story of nonoxynol 9.

  • Journal of acquired immune deficiency syndromes
  • 2005
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Safety and efficacy of dapivirine vaginal ring for HIV-1 prevention in african women, CROI – Conference on Retrovirus and Opportunistic Infections

A. Nel, S. Kapiga, +3 authors Z. Rosenberg
  • 2016
VIEW 1 EXCERPT

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