Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation.

@article{Kim2012DevelopmentAI,
  title={Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation.},
  author={Jun Sung Kim and Young-Hwa Kim and Jin Hyun Kim and Keon Wook Kang and Eunju Lee Tae and Hyewon Youn and Daehong Kim and Seok Ki Kim and Jung-Taek Kwon and M. -Il Cho and Yun-Sang Lee and Jae Min Jeong and June-Key Chung and Dong Soo Lee},
  journal={Nanomedicine},
  year={2012},
  volume={7 2},
  pages={219-29}
}
AIM To monitor cells in vivo or to detect the sentinel lymph node, we developed a PET/MRI silica nanoprobe with an enhanced near-infrared fluorescence signal. METHODS We developed enhanced near-infrared fluorescent (NIRF) magnetic silica nanoparticles, MNP-SiO2(NIR797), that encapsulate NIRF dye in the silica. We applied this probe to visualizing cells in the deep tissue of mice using NIRF imaging. After labeling with a radioisotope, (68)Ga, on the surface of MNP-SiO2(NIR797), we injected it… CONTINUE READING
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