Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery.

@article{Zupani2017DevelopmentAI,
  title={Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery.},
  author={O{\vz}bej Zupan{\vc}i{\vc} and Julia Rohrer and Hung Thanh Lam and Julia Anita Griessinger and Andreas Bernkop-Schn{\"u}rch},
  journal={Drug development and industrial pharmacy},
  year={2017},
  volume={43 10},
  pages={1694-1702}
}
AIM In this study, self-emulsifying drug delivery system (SEDDS) for oral delivery of opioid peptide dalargin were developed and characterized in vitro. METHODS Dalargin lipophilicity was increased by O-esterification of tyrosine OH group, hydrophobic ion pairing, or a combination thereof. Distribution coefficients (log D) of lipidized dalargin… CONTINUE READING