Development and in Vitro Evaluation of Mucoadhesive Bilayer Buccal Tablets of Carvedilol

@inproceedings{Abdelbary2015DevelopmentAI,
  title={Development and in Vitro Evaluation of Mucoadhesive Bilayer Buccal Tablets of Carvedilol},
  author={Ahmed Abd-elbary and Amna Awad Makky and Mina Ibrahim Tadros and Ahmed Adel Alaa-Eldin},
  year={2015}
}
Objectives: Carvedilol (CVD) is a nonselective β-adrenergic blocker that suffers from low absolute bioavailability (25-35%) due to first-pass metabolism. CVD-loaded buccal tablets were developed as a promising approach to overcome this limitation. Methods: The bilayers tablets were prepared by the direct compression technique. CVD-containing layer was based… CONTINUE READING