Development and heterogeneity of macrophages and their related cells through their differentiation pathways

@article{Takahashi1996DevelopmentAH,
  title={Development and heterogeneity of macrophages and their related cells through their differentiation pathways},
  author={Kazuhiro Takahashi and Makoto Naito and Motohiro Takeya},
  journal={Pathology International},
  year={1996},
  volume={46}
}
Macrophages are a heterogeneous population differing In their site of location, morphology and function. They develop from hematopoletic stem cells originating In both fetal and bone marrow hematopolesls. In yolk sac and early hepatic hematopoiesls, primitive/fetal macrophages develop from hematopoletic stem cells, bypassing the stage of monocytic cells (monoblasts, promonocytes and monocytes), possess proliferatlve capacity and differentiate into resident macrophages in tissues in late… Expand
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References

SHOWING 1-10 OF 184 REFERENCES
Immunophenotypic and ultrastructural heterogeneity of macrophage differentiation in bone marrow and fetal hematopoiesis of mouse in vitro and in vivo
  • Yuki Morioka, M. Naito, Tatsuo Sato, Kiyoshi Takahashi
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1994
TLDR
The results imply that CSFs are important factors for the generation of phenotypic heterogeneity of macrophage populations not only in bone marrow but also in fetal hematopoiesis, suggesting that there are different pathways of Macrophage differentiation. Expand
Development, Differentiation, and Maturation of Macrophages in the Fetal Mouse Liver
TLDR
It appears that there exist two different macrophage populations, a primitive/ fetal macrophages population and a monocyte/macrophage population in hepatic hematopoiesis, and it also appears that fetalMacrophages are differentiated from primitive Macrophages which are colonized into the fetal liver from the yolk sac or which develop in loco, presumably from hematoplastic stem cells. Expand
CFU-rAM, the origin of lung macrophages, and the macrophage lineage.
TLDR
It appears that central hematopoietic tissues (bone marrow, spleen) may generate macrophages by a direct pathway from early-committed progenitors as well as indirectly through a series of intermediate stem cells. Expand
Ontogenic development of macrophage subpopulations and la‐positive dendritic cells in fetal and neonatal rat spleen
  • M. Takeya, Kiyoshi Takahashi
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1992
TLDR
The results suggest that ED2+ macrophages, TRPM‐3+ Macrophage subpopulations, and Ia+ dendritic cells are distinct cell lines that pursue independent developmental processes in spleen ontogeny. Expand
Development, Differentiation, and Maturation of Macrophages in the Chorionic Villi of Mouse Placenta With Special Reference to the Origin of Hofbauer Cells
TLDR
With the progress of gestation, the monocyte/macrophage population appeared in the chorionic villous stroma, forming a heterogeneous population of placental macrophages in the late fetal stage. Expand
Ontogenetic development, differentiation, and phenotypic expression of macrophages in fetal rat lungs
TLDR
In the fetal stage, both RM‐1+ and ED2+ macrophage subpopulations showed proliferative potential, suggesting their ability to proliferate and survive in vivo. Expand
Precursors of macrophages in embryonic rat lungs fail to exhibit granulocyte‐forming potential
TLDR
The question of whether the macrophage population developed in explants is increased by exposure to M‐ and GM‐colony‐stimulating factors (CSFs) but is unaffected by multi (IL‐3)‐ or granulocyte (G)‐CSF is examined in organ cultured 14 day prenatal rat lungs. Expand
Embryonic origin of the mouse macrophage.
TLDR
It is concluded that the early fetal yolk sac is the embryonic site of origin of the macrophage precursor and that this precursor is “proximal” to the promonocyte on the pathway of sequential macrophages maturation. Expand
Differentiation, Maturation, and Proliferation of Macrophages in the Mouse Yolk Sac: A Light‐Microscopic, Enzyme‐Cytochemical, Immunohistochemical, and Ultrastructural Study
TLDR
The results suggest that fetal macrophages differentiate from primitive macrophage before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. Expand
Differences between monocyte-derived and tissue macrophages.
TLDR
The conclusion was drawn that two types of macrophages exist: exudate and resident macrophage, the former being directly derived from monocytes, and the latter being directlyderived from tissue Macrophages. Expand
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2
3
4
5
...