Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

@article{Schorle1991DevelopmentAF,
  title={Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting},
  author={Hubert Schorle and Thomas Holtschke and Thomas H{\"u}nig and Anneliese Schimpl and Ivan Horak},
  journal={Nature},
  year={1991},
  volume={352},
  pages={621-624}
}
INTERLEUKIN-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1–3). IL-2 is, however, not the sole T-cell growth factor4,5, nor does it act exclusively on T cells, also promoting growth of NK cells6 and differentiation of B cells7. A role for IL-2 in T-cell development… CONTINUE READING
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