Development and evaluation of cationic amphiphilic antimicrobial 2,5‐diketopiperazines

@article{Labrire2018DevelopmentAE,
  title={Development and evaluation of cationic amphiphilic antimicrobial 2,5‐diketopiperazines},
  author={Christophe Labri{\`e}re and N. Kondori and J. S. Caous and Marc Boomgaren and K. Sandholm and K. Ekdahl and J{\o}rn H Hansen and J. Svenson},
  journal={Journal of Peptide Science},
  year={2018},
  volume={24}
}
Both pathogenic bacteria and fungi are developing resistance to common antimicrobial treatment at an alarming rate. To counteract this development, it is of essence to develop new classes of antimicrobial agents. One such class is antimicrobial peptides, most of which are derived from the innate immune system. In this study, a series of novel 2,5‐diketopiperazines were designed, synthesized, and evaluated for their antimicrobial abilities. The compounds were designed to probe the pharmacophore… Expand
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