Development and evaluation of carboplatin-loaded PCL nanoparticles for intranasal delivery.

@article{Alex2016DevelopmentAE,
  title={Development and evaluation of carboplatin-loaded PCL nanoparticles for intranasal delivery.},
  author={Angel Treasa Alex and Alex C Joseph and Gopal Venktesh Shavi and Josyula Venkata Rao and Nayanabhirama Udupa},
  journal={Drug delivery},
  year={2016},
  volume={23 7},
  pages={2144-2153}
}
CONTEXT The study was aimed to develop a polymeric nanoparticle formulation of anticancer drug carboplatin using biodegradable polymer polycaprolactone (PCL). The formulation is intended for intranasal administration to treat glioma anticipating improved brain delivery as nasal route possess direct access to brain and nanoparticles have small size to overcome the mucosal and blood-brain barrier. OBJECTIVE Development and evaluation of carboplatin-PCL nanoparticles for brain delivery by nasal… CONTINUE READING