Development and evaluation of an improved mouse model of meningococcal colonization.

@article{Yi2003DevelopmentAE,
  title={Development and evaluation of an improved mouse model of meningococcal colonization.},
  author={Kyungcheol Yi and David S. Stephens and Igor Stojiljkovi{\'c}},
  journal={Infection and immunity},
  year={2003},
  volume={71 4},
  pages={1849-55}
}
Studies of meningococcal pathogenesis have been severely restricted due to the absence of an adequate animal model. Given the significance of iron in meningococcal pathogenesis, we developed a model of Neisseria meningitidis colonization in outbred adult mice that included daily administration of iron dextran. While receiving iron, the animals were… CONTINUE READING