Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

@inproceedings{Konsti2011DevelopmentAE,
  title={Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer},
  author={Juho Konsti and Mikael Lundin and Heikki Joensuu and Tiina T. Lehtim{\"a}ki and Harri Sihto and Kaija A Holli and Taina M. Turpeenniemi-Hujanen and Vesa V. Kataja and Liisa Sailas and Jorma J. Isola and Johan Lundin},
  booktitle={BMC clinical pathology},
  year={2011}
}
BackgroundThe aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients with breast cancer.MethodsUsing a previously reported virtual microscopy platform and an open source image processing tool, ImageJ, a method for assessment of immunohistochemically (IHC) stained area and intensity was created. A tissue microarray (TMA) series of breast cancer… CONTINUE READING
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