Development and evaluation of a new water-soluble iodinated myelographic contrast medium with markedly reduced convulsive effects.


A new water-soluble myelographic contrast agent with more hydrophilic properties than metrizamide was developed and tested in the primate (Macaca mulatta) and the cat. A new animal model that allows study of the convulsive effects of intrathecally administered contrast agents in the awake monkey was designed. With this sensitive model the new contrast agent… (More)


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