Development and clinical validation of an in situ biopsy-based multimarker assay for risk stratification in prostate cancer.

  title={Development and clinical validation of an in situ biopsy-based multimarker assay for risk stratification in prostate cancer.},
  author={Peter Blume-Jensen and David M. Berman and David L. Rimm and Michail V. Shipitsin and Mathew Putzi and Thomas P. Nifong and Clayton G. Small and Sibgat A. Choudhury and Teresa Capela and L Coupal and Christina Ernst and Aeron Hurley and Alex Kaprelyants and Hua Chang and Eldar Giladi and Julie Nardone and James Dunyak and Massimo F. Loda and Eric A Klein and Cristina Magi-Galluzzi and Mathieu Latour and Jonathan I. Epstein and Philip W. Kantoff and Fred Saad},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={21 11},
PURPOSE Prostate cancer aggressiveness and appropriate therapy are routinely determined following biopsy sampling. Current clinical and pathologic parameters are insufficient for accurate risk prediction leading primarily to overtreatment and also missed opportunities for curative therapy. EXPERIMENTAL DESIGN An 8-biomarker proteomic assay for intact tissue biopsies predictive of prostate pathology was defined in a study of 381 patient biopsies with matched prostatectomy specimens. A second… CONTINUE READING
36 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error

  • ShipitsinM, C Small, S Choudhury, E Giladi, S Friedlander, J Nardone
  • Br J Cancer
  • 2014
Highly Influential
5 Excerpts

clinical practice guidelines in oncology: prostate cancer

  • Version 3.2012. Available from: http://www.nccn…
  • 2014
Highly Influential
20 Excerpts

Outcome of primary versus deferred radical prostatectomy in the Clin Cancer Res

  • HolmstromB, E Holmberg, L Egevad, J Adolfsson, JE Johansson, J Hugosson
  • Cancer Outcomes on April
  • 2015

Cancer statistics ,

  • JI Epstein
  • 2014

Similar Papers

Loading similar papers…