Development and characterization of recA mutants of Campylobacter jejuni for inclusion in attenuated vaccines.

@article{Guerry1994DevelopmentAC,
  title={Development and characterization of recA mutants of Campylobacter jejuni for inclusion in attenuated vaccines.},
  author={Pascal Guerry and Patricia Marie Pope and Donald Burr and J Leifer and Sam W. Joseph and August Louis Bourgeois},
  journal={Infection and immunity},
  year={1994},
  volume={62 2},
  pages={426-32}
}
Isogenic recA mutants of Campylobacter jejuni have been constructed for evaluation of their usefulness in attenuated vaccines against this major worldwide cause of diarrhea. The recA+ gene of C. jejuni 81-176 was cloned by using degenerate primers to conserved regions of other RecA proteins in a PCR. The C. jejuni recA+ gene encodes a predicted protein with an M(r) of 37,012 with high sequence similarity to other RecA proteins. The termination codon of the recA+ gene overlaps with the… CONTINUE READING
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