Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate.

@article{Danielpour1994DevelopmentAC,
  title={Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate.},
  author={David Danielpour and Kenji Kadomatsu and Mario A. Anzano and Joseph A. M. Smith and Michael B. Sporn},
  journal={Cancer research},
  year={1994},
  volume={54 13},
  pages={3413-21}
}
We have established two new epithelial cell lines (NRP-152, NRP-154), with markedly different properties, from the dorsal-lateral prostate of Lobund/Wistar rats treated with N-methyl-N-nitrosourea and testosterone propionate. NRP-152 cells do not form tumors in athymic mice and retain many of the properties of normal prostatic epithelial cells. They produce prostatic acid phosphatase, have functional androgen receptors, and require the combination of several growth factors in addition to serum… CONTINUE READING