Development and characterization of monoclonal antibodies to chicken interleukin-15.

  title={Development and characterization of monoclonal antibodies to chicken interleukin-15.},
  author={Wongi Min and Hyun Soon Lillehoj and Guangxing Li and Eun Jung Sohn and Tadashi Miyamoto},
  journal={Veterinary immunology and immunopathology},
  volume={88 1-2},
The chicken IL-15 gene was recently cloned and shown to encode a polypeptide with T cell growth factor activity similar to IL-2. To further characterize the chemical and biological properties of chicken IL-15, we generated a panel of monoclonal antibodies against bacterially expressed protein and characterized their binding specificities. All antibodies were reactive by ELISA with recombinant IL-15, but not IL-2, and identified a 15kDa recombinant chicken IL-15 by Western blot analysis. Two… CONTINUE READING

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