Development and characterization of continuous avian cell lines depleted of mitochondrial DNA

  title={Development and characterization of continuous avian cell lines depleted of mitochondrial DNA},
  author={R{\'e}jean Morais and Paul Desjardins and Chanta Turmel and Karen Zinkewich-P{\'e}otti},
  journal={In Vitro Cellular & Developmental Biology},
Populations of quail and chicken cells were treated with ethidium bromide, an inhibitor of mitochondrial DNA replication. After long-term exposure to the drug, the cell populations were transferred to ethidium bromide (EtdBr)-free medium, and cloned. Clones HCF7 (quail) and DUS-3 (chicken) were propagated for more than a year, and then characterized. Analysis of total cellular DNA extracted from these cells revealed no characteristic mitochondrial DNA molecule by Southern blot hybridization of… CONTINUE READING
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