Development and characterization of an animal model of severe pulmonary arterial hypertension.

Abstract

Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor prognosis, which is associated with morphological as well as hemodynamic alteration of the pulmonary circulation. To establish an animal model mimicking severe human PAH, we combined 2 well-described procedures, i.e. exposure to hypobaric chronic hypoxia and administration… (More)
DOI: 10.1159/000329594

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Cite this paper

@article{Morimatsu2012DevelopmentAC, title={Development and characterization of an animal model of severe pulmonary arterial hypertension.}, author={Yoshitaka Morimatsu and Naomi Sakashita and Yoshihiro Komohara and Koji Ohnishi and Hiroshi Masuda and Diana Dahan and Motohiro Takeya and Christelle Guibert and Roger Marthan}, journal={Journal of vascular research}, year={2012}, volume={49 1}, pages={33-42} }