Development and characterization of a nano-scale contrast agent.

  title={Development and characterization of a nano-scale contrast agent.},
  author={Brian E Oeffinger and Margaret A. Wheatley},
  volume={42 1-9},
Agents injected parenterally must be less than approximately 8 microm diameter in order to traverse the capillaries in the pulmonary bed, but these agents remain in the vasculature until they are eliminated from the body by a variety of mechanisms. Targeting of cells outside the capillaries requires agent diameters of less than approximately 700 nm to enable escape through the larger-than-usual pores that have been noted in the leaky vasculature of a tumor. The objective of this study was to… CONTINUE READING


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