Development and characterization of a mouse model for Marburg hemorrhagic fever.

@article{Warfield2009DevelopmentAC,
  title={Development and characterization of a mouse model for Marburg hemorrhagic fever.},
  author={Kelly Lyn Warfield and Steven B. Bradfute and Jay Wells and Loreen L. Lofts and Meagan T Cooper and Derron A. Alves and Daniel K Reed and Sean A. Vantongeren and Christine A Mech and Sina Bavari},
  journal={Journal of virology},
  year={2009},
  volume={83 13},
  pages={6404-15}
}
The lack of a mouse model has hampered an understanding of the pathogenesis and immunity of Marburg hemorrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the development of antiviral therapeutics. Primary isolates of the filoviruses, i.e., ebolavirus (EBOV) and MARV, are not lethal to immunocompetent adult mice. Previously, pathological, virologic, and immunologic evaluation of a mouse-adapted EBOV, developed by sequential passages in suckling mice… CONTINUE READING

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