Development and characterization of a long-acting nanoformulated abacavir prodrug.

@article{Singh2016DevelopmentAC,
  title={Development and characterization of a long-acting nanoformulated abacavir prodrug.},
  author={Dhirender Singh and JoEllyn McMillan and James R Hilaire and Nagsen Gautam and Diana L. Palandri and Yazen M Alnouti and Howard E. Gendelman and Benson J. Edagwa},
  journal={Nanomedicine},
  year={2016},
  volume={11 15},
  pages={1913-27}
}
AIM A myristoylated abacavir (ABC) prodrug was synthesized to extend drug half-life and bioavailability. METHODS Myristoylated ABC (MABC) was made by esterifying myristic acid to the drug's 5-hydroxy-cyclopentene group. Chemical composition, antiretroviral activity, cell uptake and retention and cellular trafficking of free MABC and poloxamer nanoformulations of MABC were assessed by proton nuclear magnetic resonance and tested in human monocyte-derived macrophages. Pharmacokinetics of ABC… CONTINUE READING