Development and characterization of a live attenuated influenza B virus vaccine candidate.


A human influenza B/Lee/40 virus was cold-adapted by serial passages in embryonated chicken eggs, at progressively lower temperatures, for possible use as a future influenza B vaccine donor strain. Temperature sensitive and cold-adapted phenotypes were achieved as a consequence of the adaptation process. It was determined that the virus was attenuated in… (More)
DOI: 10.1016/j.vaccine.2007.12.022