Development and characterization of a bladder cancer xenograft model using patient-derived tumor tissue.

@article{Park2013DevelopmentAC,
  title={Development and characterization of a bladder cancer xenograft model using patient-derived tumor tissue.},
  author={Bumsoo Park and Byong Chang Jeong and Yoon-La Choi and Ghee Young Kwon and Joung Eun Lim and Seong Il Seo and Seong Soo Jeon and Hyun Moo Lee and Han Yong Choi and Kyu-Sung Lee},
  journal={Cancer science},
  year={2013},
  volume={104 5},
  pages={631-8}
}
Most of the cancer xenograft models are derived from tumor cell lines, but they do not sufficiently represent clinical cancer characteristics. Our objective was to develop xenograft models of bladder cancer derived from human tumor tissue and characterize them molecularly as well as histologically. A total of 65 bladder cancer tissues were transplanted to immunodeficient mice. Passagable six cases with clinico-pathologically heterogeneous bladder cancer were selected and their tumor tissues… CONTINUE READING
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