Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol.

@article{Carson1996DevelopmentAC,
  title={Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol.},
  author={Elizabeth Carson and Stephen B Pruett},
  journal={Alcoholism, clinical and experimental research},
  year={1996},
  volume={20 1},
  pages={132-8}
}
This study describes the development and characterization of a binge drinking model in which a single dose of ethanol (EtOH) is administered by gavage to B6C3F1 mice. Blood EtOH levels were monitored over time after administration of EtOH at doses of 3.0-7.0 g/kg. Peak levels were in the range of 0.2-0.5%, and clearance was complete within 2-12 hr. Substantial increases in blood corticosterone levels were noted. Behavioral changes in EtOH-treated mice aged 8 weeks ranged from no effect (3-4 g… CONTINUE READING