Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts.

@article{Kimple2013DevelopmentAC,
  title={Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts.},
  author={Randall J. Kimple and Paul M. Harari and Alexandra D. Torres and Robert Z. Yang and Benjamin J Soriano and Menggang Yu and Eric A. Armstrong and Grace C. Blitzer and Molly A. Smith and Laurel D. Lorenz and Denis Lee and David T Yang and Timothy M McCulloch and Gregory K. Hartig and Paul F Lambert},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 4},
  pages={855-64}
}
PURPOSE To develop a clinically relevant model system to study head and neck squamous cell carcinoma (HNSCC), we have established and characterized a direct-from-patient tumorgraft model of human papillomavirus (HPV)-positive and HPV-negative cancers. EXPERIMENTAL DESIGN Patients with newly diagnosed or recurrent HNSCC were consented for donation of tumor specimens. Surgically obtained tissue was implanted subcutaneously into immunodeficient mice. During subsequent passages, both formalin… CONTINUE READING
28 Citations
22 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Similar Papers

Loading similar papers…