Development and characterisation of chitosan nanoparticles for siRNA delivery.

  title={Development and characterisation of chitosan nanoparticles for siRNA delivery.},
  author={Haliza Katas and H Oya Alpar},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={115 2},
Gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for diseases with genetic defects. The use of siRNA, however, is hampered by its rapid degradation and poor cellular uptake into cells in vitro or in vivo. Therefore, we have explored chitosan as a siRNA vector due to its advantages such as low toxicity, biodegradability and biocompatibility. Chitosan nanoparticles were prepared by two methods of ionic cross… CONTINUE READING
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