Development and biological applications of chloride-sensitive fluorescent indicators.

@article{Verkman1990DevelopmentAB,
  title={Development and biological applications of chloride-sensitive fluorescent indicators.},
  author={Alan Samuel Verkman},
  journal={The American journal of physiology},
  year={1990},
  volume={259 3 Pt 1},
  pages={
          C375-88
        }
}
Chloride movement across cell plasma and internal membranes, is of central importance for regulation of cell volume and pH, vectorial salt movement in epithelia, and, probably, intracellular traffic. Quinolinium-based chloride-sensitive fluorescent indicators provide a new approach to study chloride transport mechanisms and regulation that is complementary to 36Cl tracer methods, intracellular microelectrodes, and patch clamp. Indicator fluorescence is quenched by chloride by a collisional… CONTINUE READING
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